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Alleviating Cancer Drug Toxicity by Inhibiting a Bacterial Enzyme

Alleviating Cancer Drug Toxicity by Inhibiting a Bacterial Enzyme

The dose-limiting side effect of the common colon cancer chemotherapeutic CPT-11 is severe diarrhea caused by symbiotic bacterial β-glucuronidases that reactivate the drug in the gut. We sought to target these enzymes without killing the commensal bacteria essential...

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Cancer and the gut microbiota: An unexpected link

Cancer and the gut microbiota: An unexpected link

Accumulating evidence demonstrates that intestinal bacteria influence oncogenesis, tumor progression, and response to therapy. Thus, selectively manipulating the gut microbiota may represent a feasible means to limit the incidence of specific tumors in the general...

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