Microbiota contributions
Intratumoral microbiota have been described in various human cancers. In Nature, Bullman and colleagues use in situ spatial-profiling technologies and single-cell RNA sequencing (scRNA-seq) to map host–bacterial interactions within the tumour microenvironment. In oral...
The promise and challenge of cancer microbiome research
The human microbiome is a significant community, with an estimated ratio of one microbial cell per human cell [1] and nearly 500-fold more microbial genes than host genes [2]. This community is dynamically shaped alongside human development from birth through...
Pan-cancer analyses reveal cancer-type-specific fungal ecologies and bacteriome interactions
Cancer-microbe associations have been explored for centuries, but cancer-associated fungi have rarely been examined. Here, we comprehensively characterize the cancer mycobiome within 17,401 patient tissue, blood, and plasma samples across 35 cancer types in four...
